ProteoGenix Publishes Key Study of Intra-amniotic Infection - Journal of the American Medical Association

ProteoGenix Publishes Identification of Novel Biomarkers in Cervical-Vaginal Fluid for Noninvasive Detection of Intra-amniotic Infection in Journal of Proteome Research

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Intra-amniotic infection (IAI) is associated with preterm birth and perinatal mortality. To identify potential biomarkers, we performed a comprehensive survey of the cervical-vaginal fluid (CVF) proteome from a primate IAI model utilizing multidimensional protein identification technology (LC/LC-MS/MS) and MALDI-TOF-MS analyses. Analyses of CVF proteome identified 205 unique proteins and differential expression of 27 proteins in controls and IAI samples. Protein expression signatures and immunodetection of specific biomarkers identified can be employed for noninvasive detection of IAI.

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Proteogenix

Careers at ProteoGenix Director, Human Resources Director, Immunodiagnostics Product Development Research Associate, Immunodiagnostics Product Development

Management Board of Directors Research Staff

Intra-amniotic Infection Pre-term Birth Down Syndrome

Oregon Health & Science University Beckman Coulter Eli Lilly

Genomics Proteomics Metabolomics Bioinformatics

ProteoGenix Publishes Four Landmark Articles on Diagnostic Applications for Pregnancy (Journal of Proteome Research, April 2007) ProteoGenix Receives Best Clinical Study Award at SMFM Annual Meeting for Preterm Birth and Intra-amniotic Infection (February 2007) ProteoGenix Publishes Identification of Novel Biomarkers in Cervical-Vaginal Fluid for Noninvasive Detection of Intra-amniotic Infection (Journal of Proteome Research, January 2007) Test May Prevent Premature Births (BBC, July 2004) Discovery Could Help Prevent Premature Births (CNN and Associated Press, July 2004) Protein Linked to Premature Births (MSNBC and Associated Press, July 2004) OHSU test targets premature births: Scientists are developing a simple blood screening that could cut the number of risky early births nearly in half. (The Oregonian, July 2004) ProteoGenix Publishes Key Study of Intra-amniotic Infection (Journal of the American Medical Association, July 2004) ProteoGenix Scientists Describe Novel Mass Spec Algorithm (Analytical Chemistry, July 2004) ProteoGenix Receives NIH SBIR Award for "Diagnositic proteiomic profiles for aneuploidy" November 2003

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