IAI is a critical complication of pregnancy and is associated with significantly risk of morbidity. The table below summarizes published clinical results demonstrating neonates born in the setting of IAI had a 2.7 times to 3.4 times higher risk of complications such as neonatal sepsis, respiratory distress syndrome, intraventricular hemorrhage, as compared to a similar group of neonates born outside the setting of IAI, but matched for other variables such as gestational age, birth weight, preterm rupture of membranes, preeclampsia andcesarean birth:



In addition:

• IAI is associated with at least one-third of all early-onset neonatal sepsis and pneumonia in United States.⁶

• IAI also accounts for highest proportion of neonatal deaths in the United States and up to 40% of cases of maternal febrile morbidity in the peripartum period.⁷

• A study published in JAMA demonstrated a clear link between IAI and cerebral palsy via meta-analysis of 19 published studies.⁸

• IAI is also responsible for a disproportionate share of aggregate prenatal healthcare costs (estimated in the United States to be $4 to $6 billion annually).⁹